Greener Method for Synthesis of Medicinally Potent Indole Derivatives. Indole Derivatives by Green approach

      Аннотация: The present book entitled “Greener method for synthesis of medicinally potent indole derivatives” deals with the synthesis of azepine derivatives from conjugated ketones and pyrazolo, isoxazolo and pyrimidino from chalcones. Both of which were (conjugated ketones and Chalcones) in turn synthesized from N-substituted indole nucleus. Ubiquity of indoles in chemical literature is undoubtedly a consequence of the multifarious biological response, which they elicit in combating a variety of body ailments. The use of this class of compounds is not merely confined to the management of hyperlipidemic related conditions but their additional novel applications have been continuously emerging.The aim of this study is to incorporate these pharmacophores which had the previous history of being biologically active on to the bioactive nucleus of indole on the premise that their presence in tandem in a single molecular framework could contribute significantly to the biological efficacy in the resulting molecules.

Ключевые слова: Indole, Mannich bases