The Role of Interim FDG-PET/CT in Pediatric Hodgkin’s Lymphoma.

      Аннотация: Purpose of the study: was to estimate the value of early assessment of response in pediatric Hodgkin lymphoma (PHL) patients using FDG-PET/CT. Methods: prospective analysis of 195 patients (CCHE) with pathologically proven untreated PHL, they underwent18 FDG PET/CT early after 2 cycles of chemotherapy (PET 2). Analysis of PET 2 was done according to the Deauville score. Results: Follow-up for mean period of 2.9 years. Visual assessment of PET 2 was found to be significantly correlated with the estimate for OS and PFS was 83.3% and 68.8 respectively in the PET-positive (PET +ve) group compared with 97.3% and 92.6|% respectively in the PET-negative (PET –ve) group (p-value <0.0001 and 0.0001). Conclusion: Early assessment of FDG-PET/CT after 2 cycles of ABVD in PHL shows potential value in prediction of OS and PFS in advanced stages (intermediate and high risk patients). Key words: FDG-PET/CT, pediatric HL, prognosis.

Ключевые слова: prognosis, FDG-PET/CT, pediatric HL