Alternate biomarkers in predicting CD4+ T cell count in HIV patients. Biomarkers in predicting CD4+ T cell count for initiation of antiretroviral therapy in HIV patients in north western Nigeria

      Аннотация: In many resource-poor countries, most facilities do not have cyflow counter for the performance of CD4+ count analysis required for the initiation of antiretroviral therapy. CD4+ T cell count and viral load monitoring are expensive and unavailable to most human immunodeficiency virus (HIV) infected people in Africa. There is a need to have another marker of HIV infection that is less resource demanding. Studies in human immunodeficiency virus infected adults have demonstrated association of total lymphocyte count (TLC) <1200 cell/µl and subsequent disease progression or mortality. This study was carried out to determine the relationship of CD4+ T lymphocyte counts with total lymphocyte count (TLC) and immunoglobulin G (IgG) in HIV- positive on highly active antiretroviral therapy (HAART) naive patients attending Specialist Hospital Sokoto northern region, Nigeria. The study population comprised of 100 adult HIV-positive HAART naive patients aged 19-65 years. The CD4+ T cell counts and these alternate biomarkers of study participants were measured. Spearman's rank order correlation was used for statistical analysis.

Ключевые слова: Sokoto, Total Lymphocyte Count, Immunoglobulin G, CD4+ T cell count, HIV infected patients, Nigeria