Design and In vitro evaluation of Fast Dissolving Oral Films for NRT.

      Аннотация: Nicotine is one of the most addicting drugs of the twenty-first century and has had a long history of use and abuse. Nicotine is a natural plant-derived alkaloid and the addictive active chemical found in tobacco. Tobacco in the form of smoking cigars, cigarettes, and smokeless forms such as snuff, sachet, and chewing tobacco has been used by man as a central nervous system (CNS) stimulant for over 300 years. Pure Nicotine is a highly volatile liquid, Nicotine is also available as a stabilized complex (Nicotine polacrilex USP,) in most other intraoral NR products (i.e., chewing gum, lozenges, sublingual tablets, etc.). Nicotine present in NRT products is a highly purified extract obtained from the dried leaves of the tobacco plant ( Nicotiana tabacum). Nicotine is also available in more stable salt forms (i.e., hydrochloride, dihydrochloride, sulfate, tartrate, bitartarate, and salicylate). Nicotine replacement therapy (NRT) is the remedial administration of nicotine to the body by means other than tobacco, usually as part of smoking cessation. Fast dissolving oral films are a novel approch to assist the people for smoking cessation.

Ключевые слова: Nicotine replacement therapy, fast dissolving oral films, NRT