Nanofiber for control release of antiviral drug. Evaluation of Nanofiber in Viral disease (HSV)

      Аннотация: Nanofiber drug delivery systems are capable to improve therapeutic efficacy, diminish toxicity, and can be designed to control and prolong drug release by regulate the degradation rate of the polymer.The concept of multilayer nanofibrous patch will localize the formulation at a particular region of the body, thereby improving bioavailability of the drugs with low bioavailability. The increased contact time and localization of the drug added advantage of this approach would be increase in bioavailability as well as reduction in frequency of administration. The encapsulation of Acyclovir with polymeric nanopatch could be an effective approach for producing a sustained release of the drug making it suitable for oral or other routes of administration such as intrapulmonary or intravitreal.developed multilayered nanofiber formulation was found to show controlled delivery of antiviral drug (Acyclovir). The formulation showed pH-responsive drug release at small intestine and colon system. In pharmacokinetic studies in rats, developed formulation exerted sustain release with improved pharmacokinetic profile.

Ключевые слова: acyclovir, Antiviral drug, Nanofiber, Control relaese, site specific drug delivery, HSV(Herpex Simplex Viruses )