RP-HPLC Method Development & Validation of Vilazodone Hydrocholoride.

      Аннотация: Vilazodone is a serotonergic antidepressant developed by Clinical Data for the treatment of major depressive disorder. The chemical compound was originally developed by Merck KGaA (Germany). Vilazodone was approved by the FDA for use in the United States to treat major depressive disorder in January 21, 2011. Vilazodone acts as a serotonin reuptake inhibitor and 5-HT1A receptor partial agonist It has negligible affinity for other serotonin receptors such as 5-HT1D, 5-HT2A, and 5-HT2C. Till now very few methods are available to determine the drug instrumentally. This book is aiming to address that gap with vivid methodology proper explanation & description. An effort has been made to focus on the way of doing method development & validation according to official agencies (ICH) guidelines in maximum parameter along with all figures & tables. This book is written in lucid manner, so this book is must have for students who are pursuing masters & bachelor degree in pharmacy or Analytical Chemistry or any other related courses. Researcher in this field & even company personnel analyzing this type of drug will find this book very help full.

Ключевые слова: HPLC, method development, validation, Vilazodone Hydrochloride, serotonergic antidepressant