Biopolymeric Magnetic Nanocarriers for Controlled drug release. Evaluation of drug release behaviour by polymeric nanocomposites

      Аннотация: Bipolymeric magnetic nanoparticles for controlled release involve the synthesis of polymeric nanoparticles and evaluation of their drug release potential used for Magnetic drug targeting. Magnetic drug targeting is a drug delivery system that can be used in cancer treatment. Coated magnetic particles, called carriers, are very useful for delivering chemotherapeutic drugs. In the present research casein coated iron oxide nanocarriers (CCIONPs) of core shell nanostructure have been described to find application in magnetic drug targeting. The nanoparticles were loaded with cytarabine drug and its controlled release was investigated as a function of drug loading, chemical architecture of the nanocarriers, and nature of release media. Drug release data were examined by some kinetic models like zero-order, first order, and Higuchi.

Ключевые слова: Biopolymeric nanocarrier, Magnetic behaviour, Controlled drug release, drug release kinetics