Antimicrobial screening and microwave assisted synthesis of. Thiophenyl thiazole based triazolo quinoxaline derivatives

      Аннотация: The triazole nucleus is one of the most important heterocycles which is a feature of natural products and medicinal agents. Triazole nucleus is enjoying their importance as being the center of activity. The nitrogen containing heterocyclics are found in abundance in most of the medicinal compounds. The triazoles are said to be the isosters of imidazoles in which the carbon atom of imidazole is isosterically replaced by nitrogen. Triazole & its derivatives have a wide range of application. They are predominantly among the type of compounds used such as antimicrobial, anti-inflammatory, analgesic, antiepileptic, antiviral, antihypertensive, antimalarial, antianxiety, antidepressant, and antihistaminic, antitubercular agents etc. The derivatization of Triazole ring is based on the phenomenon of bioisosterism in which replacement of oxygen of oxadiazole nucleus with nitrogen triazole analogue.

Ключевые слова: microwave, thiophene, Thiazole, Triazole, Quinoxaline.