Psychotropic Drug and Oxidative Stress in ACUTE POISONING.

      Аннотация: This book provides quantitative recommendations for the intake of vitamin C and alpha lipoic acid in fast recovery and in increasing the antioxidant status of glutathione. It shows that by oral supplementation with Vitamin C and alpha lipoic acid to acute Amitriptyline poisoning cases considerable oxidative stress was reduced, and it also enhances the total antioxidant levels of these patients. This will help the acute Amitriptyline poisoning patient to recover faster, and stay in intensive care will be reduced, also supplementation of vitamin C and alpha lipoic acid reduces the long term side effects such as Amitriptyline induced delayed Neuropathy (AIDN). Oral supplementation will be more effective for chronic Amitriptyline poison cases for a longer duration and for acute Amitriptyline poisoning cases I.V. form of vitamin C and alpha lipoic acid will be more effective. Antioxidants levels were increased during treatment after supplementation with vitamin C and alpha lipoic acid. The conclusion suggests that antioxidant status of acute amitriptyline poisoning cases should be considered for more effective recovery and that diets low in antioxidants may render slow in recovery.

Ключевые слова: oxidative stress, ANTIPSYCHOTROPIC DRUG POISONING, antioxidants, CHOLINESTERASE LEVELS, Alpha lipoic acid (ALA), Vitamin C, Acetyl cholinesterase (AchE), Creatine kinase (CK)