Formulation, Evaluation of Ivermectin Cyclodextrin Inclusion Complexes.

      Аннотация: Oral drug delivery is the simplest and easiest way of drug administration, because of the greater stability, lesser bulk, accurate dosage, cheaper cost of production and easy process, solid oral dosage forms have advantages over other dosage forms. Infact, all the poorly water soluble drugs after oral administrations are not well absorbed. And thus leads to decreased inherent efficiency of drugs. Therefore, the improvement of drug solubility thereby its oral bioavailability remains one of most challenging aspects of drug development process especially for oral drug delivery system.

Ключевые слова: Ivermectin, Beta Cyclodextrin, Alpha cyclodextrin, Hydroxy propyl beta cyclodextrin, physical mixture, Kneaded systems, Solvent evaporation, Ultraviolet spectroscopy, Fourier transform infrared, scanning electron microscopy, differential scanning calorimetry, X-ray Diffraction