Transdermal delivery of Irbesartan: Microemulsion as a delivery system.

      Аннотация: Transdermal drug delivery system is a self contained, discrete pharmaceutical dosage form which when applied to the intact skin, delivers the active ingredient through the skin at a control rate into the systemic circulation. Microemulsion (MEs) is one of the approaches used to enhance drug solubility and bioavailability. Irbesartan, a poorly water soluble drug, has been found amongst other antihypertensive agents to offer advantages in safety and tolerability. Irbesartan has been found to have inter and intra patient variability and its plasma level has been reported not to increase proportionally with the dose following oral administration. The book Transdermal delivery of irbesartan: Microemulsion as a delivery system is aimed at investigating the transdermal delivery of irbesartan using microemulsion. The findings of this present investigation suggest that microemulsion could act as a good carrier for transdermal delivery of irbesartan. The work is considered to be very significant to students of medicine and pharmacy and could also act as a guide to researchers and scientists whose interest are in techniques employed to improve drug delivery.

Ключевые слова: Irbesartan, Microemulsion, skin permeatiom, Pharmacokinetics