Diabetes Solution. Antidiabetic activity and modulation of antioxidant status by Platycladus orientalis

      Аннотация: Diabetes mellitus is a clinical syndrome characterized by hyperglycaemia due to absolute or relative deficiency of insulin . This can arise in many different ways, but is most commonly due to autoimmune type 1 diabetes or to adult-onset type 2 diabetes. Dyslipidemia in diabetics can cause significant cardiac conditions. The main aim of this study was to detect the antidabetic and antioxidant activity of aqueous and petroleum ether extract of Platycladus orientalis in Streptozotocin-induced diabetic rats.Diabetes was induced in rats through an intraperitonial injection of streptozotocine (STZ) (55 mg/kg). In order to detect the antidiabetic activity, the extracts of Platycladus orientals was given orally at doses of 100 and 200 mg/kg daily for 28 days. On day 28 the serum lipid profile that is total cholesterol (TC), triglycerides (TG), low-density lipoprotein(LDL), high-density lipoprotein (HDL), very-low-density lipoprotein (VLDL), etc. were estimated.The antioxidant parameters such as superoxide dismutase (SOD), glutathione (GSH), TBRA and coronary artery disease (CAD) were also evaluated.The extracts at doses of 200 mg/kg significantly decreased the blood glucose on 28th day.

Ключевые слова: platycladus orientalis, acute toxicity, plant extract, animal model