Toxicology of Manganese Exposures. Preliminary synthesis of findings on the toxicities of manganese exposures

      Аннотация: Manganese (Mn) is an essential trace element that is required for normal physiological processes in living systems, including animals and humans. However, both low and high levels of manganese in the body fluids and drinking water have been linked to notable unwanted health effects. The mechanisms modulating these health effects are not yet well understood. The book aims to synthesize findings regarding the Mn exposures, mechanism of toxicity, toxicokinetics, and genetic polymorphism, interactions, and health effects. It also makes recommendations for further research. The book ultimately attempts to give an insight towards a better understanding of the essentiality, toxicity, mechanism of toxicity, and health effects of the exposures to Mn, leading to a possible reduction of Mn-exposure related health effects such as neurodevelopmental, behavioral and neurodegenerative disorders, morbidity, and mortality.

Ключевые слова: Manganese Exposures, Manganism, toxicology, Pharmacokinetic Modelling, PBPK Model, One Health