Biomimetic Design and Fabrication of Tissue Scaffolds. Using Computer Aided Engineering

      Аннотация: Revision with unchanged content. CATE enables a systematic application of computer-aided technologies, i.e., computer-aided design (CAD), image processing, computer-aided ma­nu­fac­tu­ring (CAM), and solid freeform fabrication (SFF) for modeling, designing, si­mulation, and manufacturing of biological tissue and organ sub­stitutes. Through the use of CATE, the design of intricate three dimensional ar­chi­tec­ture of scaffold can be realized and these scaffolds can be fabricated with re­producible accuracy to assist biologists in studying complex tissue en­gi­nee­r­ing problems. This book outlines research addressing some of the challenges in applying the CATE approach for the biomimetic design and freeform fabri­cation of tissue scaffolds. CATE enables many novel approaches in modeling, design, and fabrication of complex tissue substitutes with enhanced func­tio­nality for research in patient specific implant analysis and simulation, image guided surgical planning and scaffold guided tissue engineering. The research will also enable cell biologists and engineers to expand their scope of re­search and study in the field of tissue engineering and regenerative medicine.

Ключевые слова: Tissue engineering, tissue scaffolds, Solid Freeform Fabrication, Layered manufacturing, unit cells, direct slicing, Image reconstruction