Arsenic Toxicity and its Remediation. Groundwater Arsenic Contamination, its Carcinogenic Effects and a Potential Remedy

      Аннотация: Chronic arsenic exposure is a major environmental health concern currently affecting millions of people worldwide. Given the consequences of arsenic on human health, this study explores the effects of arsenic exposure in human population currently exposed to alarmingly high levels of arsenic. Genome-wide gene expression pattern analysis provides strong evidences for arsenic to be carcinogenic and to contribute to a well-defined spectrum of diseases. We also identify a potential bio-marker to arsenic induced carcinogenesis. This study thus provides critical insights into modus operandi of the environmental toxin arsenic. Also despite arsenic being a prominent health hazard, an effective preventive measure for treating arsenic induced toxicity eludes us. We document GARLIC to be an effective antidote to arsenic. The restorative property of garlic was attributed to its antioxidant activity, chelating efficacy, and/or oxidizing capability of trivalent arsenic to its less toxic pentavalent form. We therefore identify garlic as a potential protective regimen to arsenic induced-toxicity. We have also discussed the paradoxical therapeutic potential of arsenic in this book.

Ключевые слова: Microarray, Toxicity, Arsenic, Heavy Metal, ROS, Garlic, Arsenite, Chelation, bio-marker