Clinical spectrum of obesity: pathophysiology and mechanisms. Obesity-associated Diseases

      Аннотация: Adipose tissue secretes a variety of bioactive substances that are associated with chronic inflammation, insulin resistance, and an increased risk of type 2 diabetes mellitus. Resistin, originally described as an adipocyte-specific hormone, has been suggested to be an important link between obesity, insulin resistance and diabetes. Although its expression was initially defined in adipocytes, significant levels of resistin expression in humans are mainly found in mononuclear leukocytes, macrophages, spleen and bone marrow cells. Increasing evidence indicates that resistin plays important regulatory roles apart from its role in insulin resistance and diabetes in a variety of biological processes: atherosclerosis and cardiovascular disease (CVD), non-alcoholic fatty liver disease, autoimmune disease, malignancy, asthma,inflammatory bowel disease and chronic kidney disease. PWS is the most common syndrome of human obesity involving disruption of the normal neuroendocrine control of energy balance

Ключевые слова: obesity, Diseases, pathophysiology, Spectrum, Health, Weight