Montelukast and Alzheimer Disease: A Comprehensive Review. Montelukast an Optimal Selection for Alzheimer Disease

      Аннотация: Alzheimer’s disease (AD), is considered as one of the most prominent, multifactorial, age-related neurodegenerative disease in the world. The treatments that have been developed up to now, have only an auxiliary effect & not therapeutic or curative. The real cause of AD is still being a mystery for the researchers since the first description of the disease over 100 years ago. The arena of AD hypothesis is continuously expanding, which provides a better cognition of AD and the development of new medication for reducing the symptoms & offering a better life for AD patients. Neuroinflammation is considered as one underlining cause of brain aging & neurodegenerative diseases. The cysteinyl leukotrienes (CycLTs) have an important role in maintaining the physiological conditions & in the development of some pathological conditions. Lately, there have been several researches that elucidated the role of CycLTs for several neurological perplexities accountable for the progress of AD. Herein, the effects of CycLTs in the development of AD will be summarized & highlight the effectiveness of CycLTs inhibitors, especially Montelukast Sodium (MON) in the treatment of AD in the near future.

Ключевые слова: ALZHEIMER’S DISEASE, CycLTs inhibitors, Montelukast, neurodegenerative disease, neuroinflammation.