Correlation of Caveolin-1 with VEGF in Osteosarcoma. Caveolin-1 expression together with VEGF can be a predictor for lung metastasis and poor prognosis in Osteosarcoma

      Аннотация: Caveolin-1, the major protein component of caveolae, plays vital functions in tumorigenesis and metastasis. Previous evidence demonstrated the positive role of Caveolin-1 in the regulation of endothelial cell differentiation and the involvement of Caveolin-1 in vascular endothelial growth factor (VEGF) mediated angiogenesis. The correlation of caveolin-1 expression and angiogenesis is not yet elucidated in osteosarcoma. This study included 66 formalin-fixed and paraffin embedded osteosarcoma tissue samples. The expression levels of Caveolin-1 and VEGF were assessed by immunohistochemistry. Then correlations with clinicopathological variables and the relationship between both markers were evaluated statistically. We also investigated the expression of Caveolin-1 and VEGF genes in Microarrays of osteosarcoma patients by using GEO data sets.Our results suggest that Caveolin-1 may act as a tumor suppressor in osteosarcoma and can be used as an indicator for poor prognosis. Also, overexpression of VEGF is a predictor of pulmonary metastasis and poor prognosis. Furthermore, there was a significant inverse correlation between Caveolin-1 and VEGF.

Ключевые слова: caveolin-1