Targeting Cancer Cell Signaling by Natural Products. An Insight into the Anticancer Potentials of Natural Products

      Аннотация: Cancer is a global epidemic, the prevalence of which is increasing every year and it accounts for a higher rate of morbidity and mortality. Numerous signaling pathways are involved in the onset and progression of different types of cancers; among these, the toll like receptor pathway, Akt-PKB-mTOR pathway, MAPK and heat shock protein signaling are important. These signaling cascades provide the cancer cells with growth advantages as well as a high rate of survival. Hence, the latest trends in cancer treatment are to target these signaling events by various synthetic and natural products. A variety of natural products and an array of bioactive components have been discovered or isolated from the plants, which are capable of targeting the cancer by modulating cellular signaling cascades. Further, these bioactive components owe a reduced secondary effect when compared to the synthetic anticancer drugs. Several such drugs have emerged and are being used in clinical medicine and a volume of these are in phase and preclinical trials. The present book aims to provide an outline on these natural products and their involvement in regulating cancers.

Ключевые слова: Cancer, Natural products, anticancer activity, Toll like receptor, Heat Shock Proteins, Glutathione