The Cardioprotective Effect. The Cardioprotective Effect of Argemone Mexicana On Doxorubicin and Isoproterenol Induced Cardiac Toxicity in Rats

      Аннотация: Cardiovascular diseases comprise the most prevalent serious disorders in the developed nations. In similar to Doxorubicin (antitumor) & Isoprenalin (a synthetic catecholamine and beta adrenergic receptor) has been found to cause severe cardiac damage The interest to undertake this investigation is due to Argemone mexicana could be a potential source of natural antioxidant, that could have greater importance as medicinal agent in blocking or slowing oxidative stress related degenerative diseases. Argemone mexicana have been reported for in vitro Anti-oxidant activity. The present study aimed to evaluate cardioprotective potential screened in Doxorubicin & Isoproterenol induced cardiac stress in which Ethanolic Extract of Argemone mexicana Leaves (EAML 200 mg/kg,400mg/kg) were administered Doxorubicin (15 mg/kg i.p ) & Isoproterenol (85mg/kg s.c.) administered groups respectively. The present study concludes that restoration of Hemodynamic Parameters (BP,ECG), Biochemical Parameters-cardiac markers (CK-MB,LDH,SGOT), Antioxidant markers (MDA,CAT,SOD,GTH)) Histopahological indications.

Ключевые слова: Isoproterenol, Antioxidant, ecg, Blood Pressure, cardiotoxicity.