Protective effect of hydroalcoholic extract of Medicago sativaseeds. Protective effect of hydro-alcoholic extract of Medicago sativaseeds against ethylene glycol-induced urolithiasis in rat

      Аннотация: In the present study MS was proved to be antiurolithiatic by analysing biochemical parameters in urine and serum, kidney homogenate analysis and histopathological study.Urinary calcium and oxalate were increased significantly in EG-treated groups. Treatment with MS (500 mg/kg p.o.) lowered the levels of calcium excretion in urine.MS (250 mg/kg p.o.) did not found to be effective in lowering the calcium level. MS treatment was effective in lowering oxalate level. Serum calcium was decresed by MS treatment.Magnesium levels in both serum and urine were lowered by MS (250 and 500 mg/kg p.o.) treatment. Phosphorus levels were effectively lowered in serum and urine upon MS (250 and 500 mg/kg p.o.) treatment. Creatinine, UA, and urea are waste products of body and their levels rise when GFR decreases due blockage of urine flow. Levels of creatinine, UA, and urea in serum and urine were effectively lowered with MS (250 and 500 mg/kg p.o.) treatment.Kidney homogenate of the kidneys was performed to assess the levels of calcium, oxalate and % LPO, which are the primary factors for urolithiasis and consequences related to it. Treatment with MS (250 and 500 mg/kg p.o.) lowered levels of each.

Ключевые слова: Hydroalcoholic, Medicago Sativa