Metabolic Microbiology, Virology and Retrovirology. Metabolic Medicine

      Аннотация: Human metabolism and climate change can modulate the evolution of superbugs and emerging viruses. Dietary fibre and human drugs- antibiotic and non-antibiotic can modulate the gut flora producing colonic archaeal growth and endosymbiosis generating climate change, evolution of superbugs and emerging viruses and creating the disease phenotype. A low fibre diet with increase in protein and fat leads to stimulation of endosymbiotic and colonic archaeal growth. The archaea develop protective mechanism of antibiotic resistance and dominates the colonic microflora. The colonic archaea by natural selection and DNA/gene exchanges with other colonic and endosymbiotic organism transfer the genes for antibiotic resistance to other colonic flora. The colonic archaea also generates RNA viroids which are converted to DNA viroids by colonic epithelial HERV reverse transcriptase and gets integrated into the colonic genome. The RNA and DNA viroids hybridise with the viroidal and bacterial population of the gut microbiome and virobiome DNA and RNA of the gut leading to generation of new emerging viruses. This leads to generation of new bacteria, RNA and DNA viruses.

Ключевые слова: Metabolic Virology, Metabolic Microbiology, Metabolic Retrovirology