Development of Analytical Methods By Using Various Hydrotropy Methods. Estimation of solid dosage forms of some poorly water soluble drugs by using different approach of hydrotropy

      Аннотация: In the various methods of some poorly water soluble drugs and their formulation for quantitative analysis the use of organic solvents can be replaced by using hydrotropy, mixed hydrotropy and mixed solvency giving ecofriendly analytical techniqueThe main drawbacks of organic solvents include high cost, toxicity and pollution. Organic solvents possess different adverse effects caused by single exposure like dermatitis, The hydrotropic solubilization, mixed hydrotropic solubilization and mixed solvency concept provide ecofriendly spectrophotometric estimations of poorly water-soluble drugs from their bulk drug samples and various dosage forms precluding the use of organic solvents providing simple, economic, eco-friendly, safe (free from toxicity) and accurate analytical methods. We can also use better hydrotropic agents for better results.Commonly used organic solvents for spectrophotometric analysis of water insoluble drugs include methanol, ethanol, chloroform, benzene, dichloromethane, dimethyl formamide, acetonitrile, ethyl acetate, toluene, carbon tetrachloride, acetone, hexane etc.

Ключевые слова: Quality assurance