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Pesticide kinetics and its effect on enzymes activity. Toxicokinetics study of imidacloprid in male rats
В наличии
Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Heba Ezzat Nasr and Mohamed Hendawi
ISBN: 9786202525145
Год издания: 2020
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 156
Издательство: LAP LAMBERT Academic Publishing
Цена: 42107 тг
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Аннотация: Our study was carried out to investigate the insecticide, imidacloprid toxicokinetics and its biochemical alterations in Male Albino rat post-treatment with a single oral dose (20 mg/kg b.w). Imidacloprid residue in samples were quantified using HPLC and compound kinetics as distribution and elimination were subjected to a non- compartmental model in blood and other tissues. Results revealed that the trend of maximal imidacloprid concentration in different organs and body fluids at six hours post dosing was in the following order: urine > blood > lungs > brain > testes > spleen > kidney > liver > muscles.Dose regime, time sampling and predicting accurate area under the curve from zero time to 24 hours (AUC24h) were calculated and validated using toxicokinetic (TK) modeler Version 1.0; the results reflected the importance and utilizing possibility of TK modeler in toxicokinetics field. Alteration in biochemical parameters associated with imidacloprid kinetics showed significant gradual increase in liver and kidney functions parameters coincided with imidacloprid accumulation with varying quantities according to each organ then gradually decreased to the end of study.
Ключевые слова: toxicokinetics, modelling, Imidacloprid, Enzymes, residues