Spine Surgery Case Series. Can Ketamine Compensate Propofol-InducedChanges in Hemodynamic During Total IntravenousAnesthesia Induction?

      Аннотация: Objective: We conducted a prospective descriptive longitudinal study in patients undergoing elective spine orthopedic surgery from January to June 2019 in order to evaluate whether ketamine attenuates the negative impact on cardiac output and systolic volume of propofol during the induction of general anesthesia. Results: After ketamine administration, all the patients experienced CO and SV levels above the baseline. However, we observed a drop in the CO and SV after propofol administration the mean values maintained above the baseline values in all the patients.Conclusion: A targeted ketamine plasma concentration of 0.3µg/ml could be useful to attenuate propofol-induced changes on CO and SV during TIVA.

Ключевые слова: Anesthesia induction, Ketamine, Estimated continuous cardiac output, propofol, Target-controlled infusion