Orodispersible Tablets Of Rizatriptan Benzoate. Formulation And Evalution

      Аннотация: In the present investigate is an attempt towards developing a formulation of Anti-migraine drug. Innovations in the area of Oral Dispersible Tablets are aimed at both increasing the performance of the dosage form by decreasing the disintegration time and increasing the patient compliance by masking the objectionable taste of the ingredient by direct compression technique. It containing Rizatriptan Benzoate as model drug used for the treatment of migraine disease. Formulation were prepared by using different Super disintegrate and suggested nine formulation F01-F09 & prepared Oral Dispersible Tablets F01-F09 by direct compression techniques containing Croscarmellose sodium and Crospovidone as Super disintegrant in different concentration (10.5,13.0 and 15.5mg). Optimized F08 formulation containing concentration of Crospovidone 10.5mg, Pregelatinized Starch 20mg, Aspartame 5mg as sweetener and Peppermint 1mg as flavor, Mannitol 94.77mg, Microcrystalline cellulose Avicel pH 101 37.20mg &Avicel pH 102 5mg, and Mag Stearate 12mg were used and further evaluated.

Ключевые слова: formulation, evaluation, Orodiapersible, Rizatriptan, Benzoate