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Coumarin Derivatives. QSAR, Design, Synthesis And Anti-Depressant Activity
В наличии
Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Nachiket Dighe and Sanjay Bhawar
ISBN: 9786202564151
Год издания: 2020
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 92
Издательство: LAP LAMBERT Academic Publishing
Цена: 31605 тг
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Аннотация: The present research work deals with the synthesis, characterisation and to evaluate the synthesized compound for antidepressant activity of a series of coumarin derivatives. Basic coumarin is prepared by Perkin reaction, which further reacted with aryl thiourea by cyclization reaction leads to produce 3-(2-(phenylaminothiazol-4-yl)-2H-chromen-2-one. Totally twelve compounds, were synthesized by conventional method and their purity was determined by TLC and they were characterized by IR and NMR spectroscopic methods. Antidepressant activity of all the synthesized compounds was evaluated by despair swim test by using Sprague Dawley Rats. Standard drug Imipramine was used as the control. In the despair swim test, all the synthesized derivatives showed antidepressant activity. Among them three Compounds (A4, A5 and A9) showed significant antidepressant activity comparing with control drug imipramine and some compound shows mild antidepressant activity. These results are useful for the further investigation in the future.
Ключевые слова: Antidepressant activity, Coumarin, Despair swims test, Perkin Reaction, Sprague Dawley rat