Oral Drug Delivery System. Oral Thin Film/Strip

      Аннотация: Oral route is most preferable route of drug delivery due to the ease of administration, patient compliance and flexibility in formulations. The orally disintegrating tablets are available in the market providing one to two minute of disintegration time. Among fast dissolving drug delivery systems, oral strip (OST) or oral thin film (OTF) drug delivery system (DDS) is an alternative to tablets, capsules, and syrups for paediatric and geriatric patients who experience in difficulties of swallowing traditional oral solid dosage forms. This technology has been used for local action, rapid release of products and for direct systemic circulation in the oral cavity to release drug in rapid fashion. And also this delivery protect drug from first pass metabolism and improve the dissolution.Oral thin film is made up of hydrophilic polymers that rapidly dissolve on buccal cavity or on the tongue. It is also reported that the permeability of the buccal mucosa is approximately 4–4000 times greater than the skin. Hence the buccal delivery serves as an excellent platform for absorption of molecules. In a recent scenario scientist have developed new DDS is oral thin film or strip DDS.

Ключевые слова: Oral drug delivery system, thin film, Strip, Loratidine, Solvent Casting Method