Clinical, laboratory and histologic findings in chronic HCV patients. Clinical and some fibrogenesis markers versus viral load and hepatic histopathology in chronic HCV patients

      Аннотация: Even after a long and asymptomatic course of chronic hepatitis C (CHC), mild disease can progress to cirrhosis. Serial liver biopsies are the best way to diagnose and assess the severity of CHC and to monitor its progression.But liver biopsy has several limitations. That prevent the use of liver biopsy as a general screening procedure for cirrhosis. Several indirect diagnostic tests have been evaluated. These tests include clinical signs, biochemical parameters, echogenic signs and endoscopic signs.For this reasons we performed clinical examination, laboratory investigations, viral load of HCV and Quantitative detection of the level of matrix metalloproteinase-2 (MMP-2) and human TIMP-1 in the serum of patients with chronic HCV.Abdominal ultrasonography and ultrasonographic guided liver biopsy and histopathological examination of liver biopsy were also done.we aimed use non invasive tests to replace liver biopsy in follow up or monitor progress of chronic HCV especially whenever there is a risk for biopsy.

Ключевые слова: Chronic HCV, Fibrogenesis markers, Liver Biopsy, Viral Load