Formulation and Development of Grape Seed Extract for Cancer. Ethnomedicinal use, Phytochemistry and Pharmacology of Vitis Vinifera

      Аннотация: Cancer can be defined as a disease in which a group of abnormal cells grows uncontrollably by disregarding the normal rules of cell division. Normal cells are constantly subject to signals that dictate whether the cell should divide, differentiate into another cell, or die. Cancer cells develop a degree of autonomy from these signals, resulting in uncontrolled growth and proliferation. If this proliferation is allowed to continue and spread, it can be fatal. In fact, almost 90% of cancer-related deaths are due to tumor spreading – a process called metastasis. The foundation of modern cancer biology rests on a simple principle – virtually all mammalian cells share similar molecular networks that control cell proliferation, differentiation, and cell death. This book defining the medicinal value of Vitis Vinifera. Readers will find an exhaustive note on the mechanism and pharmacological action of grape seed. Toxicity evaluation of grape seed extract will provide the safety level of consumption for medicinal purposes. The work was based on the determination of therapeutic potential of Grape Seed Extract against cancer disease.

Ключевые слова: Grape seed extract (GSE), Biodegradable Chitosan Microparticles, Cancer