Fibrosis. Causes, diagnosis and location

      Аннотация: Fibrosis is a pathologic curative wound that replaces normal parenchymal tissues in such a way that they are not managed, leading to significant remodelling of the tissue and the development of permanent scar tissues. Fibrosis is known as fibrotic scar. Fibroblasts cause accidental accumulation of the extra-cellular matrix components such as collagen, leading to the formation of a permanent fibrotic scar. Repeated injuries, chronic inflammation and repair are susceptible to fibrosis. This is called scarring in response to damage, and when fibrosis comes from a single cell line, it is called a fibroma. Physiologically, the fibrosis works to deposit the connective tissue that can interfere or totally obstruct the normal organs or tissue architecture and function. The excessive deposition of the fibrous tissues as well as the process of deposition of the connective tissue in cure can be represented using fibrosis. The fibrosis induces curative and thickening of the damaged tissue by means of abnormal aggregation of extracelled matrix (ECM) proteins. It is basically an exaggerated injury healing response that impairs organ function as normal.

Ключевые слова: Fibrosis, Cirrhosis, Lung fibrosis, Bridging fibrosis, Idiopathic pulmonary fibrosis