Development and validation of HPLC and Spectrophotometricmethods. New Methods developed for Multicomponent Drug formulations

      Аннотация: This book deals with the studies carried out by the writer in this laboratory for past three years on the development and validation of HPLC & spectrophotometric methods for selected multi component drugs in their formulations need for multicomponent drug in formulation analysis by HPLC and spectrophotometric methods and validation would be discussed in detail. The literature on these selected multi component formulations for developing HPLC and spectrophotometric methods would also be reviewed here.Some of the advantages are, Speed (analysis can be accomplished in 20 minutes or less), Greater sensitivity (various detectors can be employed), Improved resolution (wide variety of stationary phases), Reusable columns (expensive columns but can be used for many analysis), Ideal for substances of low volatility, Easy sample recovery, handling and maintenance, Instrumentation lends itself to automation and quantitation (less time and labour), Precise and reproducible, Calculations are done by integrator itself and Suitable for preparative liquid chromatography on a large Scale.

Ключевые слова: Uv-Visible Chromatography, HPLC, method development, validation