Regeneration - Genetic Evolution. Regeneration Abilities of Vertebrates and Invertebrates and Relationship with Pharmacological Research

      Аннотация: Wound healing is a fundamental evolutionary adaptation with 2 possible ways: scar formation or reparative - re-generation. Scars participate in re-forming the barrier with the external environment and restoring homeostasis to injured tissues, but are well understood to represent dysfunctional replacements. In contrast, reparative re-generation is a tissue-specific program that near-perfectly replicates that which was lost or damaged. Aim of this work is to verify similarity and difference between this process un a evolutionary approach. The same verify the evolution of some factors involved in cancer development .In all this process, genetically conserved or not, there are determinate kind of program (finalistic or afinalistic) whit a start messages but also a stop when the scope is achieved (regeneration). It is clear that regeneration abilities in adult form is reduced in some superior vertebrates like humans and the same it seem related to an Introduction of adaptative immunity. Also the introduction of rigid structure like bone skeleton seem require less regenerative abilities in this more advanced metazoan organism (inibithor factor).

Ключевые слова: reparative re-generation, IN-VERTEBRATES, vertebrates, pathology, heart re-generation, Dedifferentiation, re-expression embryonic markers, Stem cells, Diabetes mellitus