Liposomes development for Treatment of Skin Warts.

      Аннотация: The objective of the research work was to design novel liposomes containing both hydrophilic and hydrophobic drug by using modified ethanol ejection method was used to formulate liposomes and optimize based on 32 full factorial design. The effect of independent variables was determined on dependent variables. The liposome formulation F9 showed higher drug entrapment and controlled drug release. Small multilamellar vesicles, with sizes ranging from about 117 to 200 nm, were successfully obtained. Results indicated a significant influence of phospholipid amounts on liposome size and encapsulation efficiency. Due to their composition variability and structural properties, liposomes are extremely versatile leading to a large number of applications including pharmaceutical, cosmetics and food industrial fields. A study showed that liposomes were not stable at high temperature but formulations are most stable when stored at lower temperature i.e. 4oC. So, in the liposomes we were successfully incorporated both hydrophilic and hydrophobic drugs and it can be further used for formulation development.

Ключевые слова: Tretinoin, Liposomes, Rotaevaporation, Wart