Synthesis of some new sodium Saccharine derivatives. Containing 1,2,3-triazole via click- reaction and study their biological activity

      Аннотация: The present work involves the synthesis of some new heterocyclic compounds derived from saccharin salt as a starting material. This work wasdivided into four parts. Part One: This part includes synthesis of N-propergel saccharine alkyl azides, 1,2,3-triazole derivatives, and hydrolysis of 1,2,3-triazoles. Part Two: this part include synthesis of new heterocyclic derivatives of Schiff bases, hydrolysis of Schiff bases and chalcone derivatives bearing 1,2,3-triazoles moieties. Part Three: this part include synthesis of new compounds such as: pyrazoline, isoxazoline, pyrimidin-2-one pyrimidin-2-thiol bearing on N-[1-{(p-acetylphenyl)-1,2,3-triazol-4-yl} methyl] saccharin moieties. Part Four: this part includes using some newly synthesized compounds in four different applications.

Ключевые слова: Saccharin, 1, 2, 3-triazole, click reaction, Schiff base, Chemistry, organic chemistry, Saccharin derivatives, Click Chemistry, Chalcone Chemistry, Chalcone derivatives, Pyrazole chemistry, Pyrazole derivatives