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Design, Synthesis, QSAR Studies of some DPP-IV Inhibitors. Design, Synthesis, QSAR studies and Biological evaluation of Novel Triazolopiperazine Based DPP-IV Inhibitors
В наличии
Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Ketaki Dhane
ISBN: 9786204211428
Год издания: 1905
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 120
Издательство: LAP LAMBERT Academic Publishing
Цена: 32599 тг
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Аннотация: Diabetes mellitus (DM) is one of the most common chronic disorder with increasing prevalence worldwide. Different classes of oral anti-hyperglycemic agents with nearly equipotent efficacy are now available; however, almost all of them are associated with one or more adverse effects. The new approaches in management of type 2 DM (T2DM) are based upon the effects of incretin hormones; Glucagon-Like Peptide-1 (GLP-1), Glucose-dependent insulinotropic peptide (GIP) and dipeptidyl peptidase (DPP-IV) inhibitors, which act via enhancing the incretin secretion. QSAR is the computer-based mathematical model which establishes a correlation between structure and its biological activity. In present studies, QSAR of one of the reported triazolopiperazine based ?-aminoamides have been studied. In present studies, an attempt was made to synthesize the novel and selective 3-amino-1-(8- (cyclopropyl(3-mercapto-4H-1,2,4-triazol-4-ylamino)methyl)-2-(trifluoromtrifluromethyl)-5,6,7,8-tetrahydro-imidazolo(4,5a)-piperidine.The details of the regressional analysis, QSAR, rationale behind design, synthesis, structural characterisation and DPP- IV enzyme inhibitory activity are presented.
Ключевые слова: Type 2 diabetes mellitus, incretin, QSAR, DPP-IV inhibitors