Multi Component Synthesis of Pyridopyrimidines. Pyridopyrimidines

      Аннотация: Multicomponent reactions has picked up surprising consideration in the field of organic synthesis and chemical biology due to the various preferences such as plausibility of a few bonds arrangement in one-step prepare in addition to significant benefits like reducing waste production, the superior atom economy, quick, efficient, and time-saving way without the separation of any intermediates, decrease of work ups, and easy straightforward experimental techniques that resulted in the green transformations. Pyridopyrimidines exhibit important biological and medicinal relevance such as antihistaminic, antimicrobial, anti-inflammatory, antihypertensive, CNS depressant, antimalarial and anticancer activities. These days, chemists are enthusiastically taking on the challenge of creating green manufactured strategies to meet the criteria of maintainable, ecologically cognizant development. As a result, solvent-free and catalyst- synthetic methods have attracted much interest for chemical industry, because of lower costs, reduced pollution, ease of purification, and mild conditions.

Ключевые слова: Pyridopyrimidines, Nanocatalysis, cyclocondensation, three-component re-action, Grinding.