Chemistry of ?-(arylhydrazono)-?-Ketoesters. ?-(Arylhydrazono)-?-Ketoesters

      Аннотация: The pyrazole nucleus has many biological activities, including several pharmaceuticals currently on the market. Thiazoles are additionally significant class of heterocyclic compounds, found in numerous powerful biologically active drugs such as Ritonavir (antiretroviral drug), Sulfathiazol (antimicrobial drug), Tiazofurin (antineoplastic drug), and Abafungin (antifungal drug). Thiazole derivatives are also known to possess several anticancer activities. Moreover, thiazolyl-pyrazole compounds were identified as as potential anticancer agents. The EGFR PTKs have been identified as interesting targets for medicinal chemistry programs especially in cancer therapy.

Ключевые слова: cyclocondensation, pyrido[2, 3-d]pyrimidine, Hydrazonoyl halides, thiones, pyrazolones, In-Silico Study, Coupling reaction, anticancer activity.