Brain infections, Viral Diseases, Covid19, Psoriasis, Arthritis.. Brain, Covid19, Psoriasis, Arthritis.

      Аннотация: Analysis of neurological infections: Encephalitis, Meningitis, Human immunodeficiency virus, Viral, Fungal, Parasitic, Bacterial infections such as Lyme disease, Tuberculosis, Syphilis, Brain abscess. Viruses reach the brain by bloodstream or peripheral nerves. Diagnosis of infection was done with brain biopsy, now with neuroimaging and analysis of cerebral spinal fluid (CSF) with polymerase chain reaction for DNA viruses, and Reverse Transcriptase for RNA viruses. Viral infections in the brain depend on penetration of the blood brain barrier and release viruses within the brain. Gene silencing with antisense oligonucleotide, complementary to an RNA target. Structure and action mechanisms of viruses and bacteria producing diseases are analyzed with emphasis in Covid19. Results: Skin. Psoriasis and Leishmaniasis. Double blind placebo control trial with polyvalent vaccine. Discussion: Double-blind, placebo-controlled with multiple doses of AS100. Lymphocyte subsets in PBMC after treatment of Psoriatics with AS100 vaccine. Patients pictures from double blind trial, before and after treatment. FACS lymphocyte subsets in Psoriatics before and after treatment. Role of blood vessels.

Ключевые слова: Neurological infections, Encephalitis, Meningitis, HIV, covid19, Blood Brain Barrier, Gene silencing, Psoriasis, Leishmaniasis, FACS Lymphocyte subsets, Psoriatic patients