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Formulation and Development of Bilayer Floating Tablets of Nifedipine. Formulation and Development of Bilayer Floating Tablets of Nifedipine Using Surface Solid Dispersion Technique
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Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Dinesh Kumar Sharma,Amulyaratna Behera and Gurudutta Pattnaik
ISBN: 9786203410877
Год издания: 1905
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 108
Издательство: LAP LAMBERT Academic Publishing
Цена: 32173 тг
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Аннотация: The aim of the present research work was to develop and formulate a bilayer floating sustained release tablet of Nifedipine. Nifedipine is an antihypertensive agent. Surface solid dispersion of Nifedipine was prepared by solvent evaporation method with different super disintegrants as a polymer for improvement of solubility resulting in improved bioavailability. Bilayer consists of two layers, immediate-release layer, and second sustained release layer, compressed in the single unit dosage form. The immediate-release layer contains surface solid dispersion of Nifedipine. The floating sustained release layer also contains surface solid dispersion of Nifedipine, HPMC K100M & HPMC K15M as sustained release polymer. The floating properties of the tablets were achieved by the use of sodium bicarbonate & citric acid which generate the gas upon contact with gastric fluid. The immediate-release layer releases the drug immediately and starts the onset of action and the floating sustained release layer floats on gastric fluid for upto12 hours and releases the drug in a sustained manner, subsequently, it prolongs the duration of action.
Ключевые слова: Floating Drug delivery System, Surface solid dispersion, Bilayer tablet, In-vitro Study
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