Pharmaceutical Applications of Some New Pyranothiazole Drug Complexes. Design, Structural Inspection, Pharmaceutical Applications and DNA Interaction of Pyranothiazole Chelates: Drug-likeness

      Аннотация: Designing of new molecular metal drugs is an important approach to tackling the ongoing danger of antioxidant, anticancer and resistance to antimicrobials. Thiazole and pyran nucleus are as a wide band of pharmacological and biologically active natural products. Most up data for thiazole fused systems, exhibit common requirements in various fields among that medicinal chemistry, as anticancer, antifungal, antibacterial, and antioxidant. Metal-drug adducts exhibiting promising therapeutic efficacy, has been focused for many investigations and is of great importance in chemistry and biology sciences. Cu(II), Fe(III) and Pd(II) have a great ability for complexation due to their small sizes and high nuclear charges. On the other hand, the interactions of transition metal complexes with DNA have been a subject of passionate research in the field of bioinorganic chemistry. Therefore, the goal optimized in this view predominantly aims at constructing a network about their stimulating spectroscopic, biological, Pharmaceutical and Interaction with DNA studies of some new pyranothiazole complexes.

Ключевые слова: DNA interaction, Pyranothiazole Chelates, Pharmaceutical Applications, Molecular Simulation, Drug-likeness Assessments, structural elucidation