Design, Development and Characterization of Bioadhesive Buccal Patches.

      Аннотация: The oral route is the one mostly preferred route by patients and clinicians. Based on our current understandings of biochemical and physiological aspects of absorption and metabolism many drugs cannot be delivered effectively through conventional oral route, because after administration are subjected to pre-systemic clearance. Extensively in liver, which often leads to a lack of significant correlation between membrane permeability, absorption and bio-availability. Recent interest has been expressed on delivery of drug to or via mucus membrane by use of adhesive material several muco-adhesive formulations are available under development and drug delivery via buccal mucosa is a novel route facilitate direct entry of drug molecules into systemic circulation, avoiding first-pass metabolism and drug degradation in harsh gastrointestinal environment, which are often associated with oral administration.

Ключевые слова: Buccal Patches, Mucoadhesion, Gliclazide, Oral mucosa