Luteal Support in IVF. Comparison Between Evidence-Based Medicine and Real-Life Practices : RESEARCH SEEKS THE FOCUS BY SCIENCE - 8th Edition

      Аннотация: Background: Luteal phase support (LPS) in assisted reproduction cycles has been widely investigated in recent years. Although progesterone represents the preferential product for luteal phase supplementation in cycles with fresh embryo transfer, there is ongoing debate as to when to start, which is the best route, dosage and duration, and whether there is a place for additional agents. Nevertheless, fertility specialists do not always adhere to evidence-based recommendations in their clinical practice. The aim of this worldwide web-based survey is to document the currently used protocols for luteal phase support and appraisal tendencies of drug prescription behavior and to compare these to the existing evidence-based literature. Material and Methods: A questionnaire was developed and sent by secure e-mail to 1,480 clinicians involved in ART worldwide. One hundred and forty-eighth clinicians from 34 countries returned completed questionnaires. Results: Progesterone support is usually started on the day of oocyte retrieval. Eighty percent of clinicians applied the administration of vaginal progesterone only.

Ключевые слова: Assisted reproductive technology (ART), in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), gamete intrafallopian transfer (GIFT);, tubal embryo transfer (TET), Medically assisted reproduction (MAR), Luteal phase support (LPS), gonadotropin releasing hormone (GnRH), estrogen (E) and progesterone (P), luteinizing hormone (LH), human chorionic gonadotropin (hCG)