Predictive Role of Biomarkers in Long Term Stability of Dental Implant. Biomarkers of Per-implant diseases

      Аннотация: The objective of this systematic review of the literature was to evaluate and summarize the diagnostic and prognostic potential of Peri Implant Crevicular Fluid(PICF). Included studies were systematically analyzed based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta Analyses) guidelines. Electronic database search of Pubmed, Medline, Google Scholar and Scopus was performed using MeSH terms and keywords-PICF and Cytokines, IL-1?, IL-6, IL-4, IL-10, IL-8, IL-17, and TNF-?, MIP-1?. Articles published between years 2000-2019 were reviewed and were included based on inclusion and exclusion criteria. Based on this systematic review of literature, the analysis of these components of PICF can reflect the disease status of individual sites and thus, identify potential biomarkers of peri-implant disease status and its application in prognostic significance and response to therapy thereby could prove to be a valuable tool in early diagnosis and management.

Ключевые слова: biomarkers, Cytokines, dental implant, peri-implant crevicular fluid, Peri-Implant Diseases