Design and Evaluation of Favipiravir Loaded Mouth Dissolving Tablets.

      Аннотация: The concept of formulation favipiravir mouth dissolving tablets is to offer a suitable approach for improving patient compliance in pediatrics, geriatrics and children, thereby avoiding side effects such as nausea and gastritis. In the present work, MDT of favipiravir was prepared successfully by wet granulation technique using super disintegrants. The different concentrations and combinations of super disintegrants such as CCS, SSG and CPV. From the experimental results, it can be concluded that pre-formulation studies like solubility and UV-analysis were complied with standards. The FT-IR spectra revealed that, there was no interaction between favipiravir and polymers. All the polymers used were compatible with favipiravir.However, the disintegration time for each formulation was not significantly affected by super disintegrants concentration. The study also indicated about the amount of drug release is also altered by super disintegrant concentration. Different super disintegrants have shown significant results while performing in-vitro studies.

Ключевые слова: favipiravir, Mouth Dissolving Tablets, super disintegrants, WET GRANULATION