Resealed Erythrocytes as a Novel Carrier for Drug. Resealed Erythrocytes

      Аннотация: Eucocytes, platelets, erythrocytes, nanoerythrocytes, hepatocytes, and fibroblasts etc. have been proposed as cellular carrier systems. Among these, the erythrocytes have been the most investigated and have found to possess greater potential in drug delivery. Biopharmaceuticals, therapeutically significant peptides and proteins, nucleic acid-based biological, antigens, anticancer drug's and vaccines, are among the recently focused pharmaceuticals for being delivered using carrier erythrocytes. Erythrocytes, also known as red blood cells, and have been extensively studied for their potential carrier capabilities for the delivery of drugs. The biocompatibility, nonpathogenicity, non-immunogenicity and biodegradability make them unique and useful carriers. Carrier erythrocytes are prepared by collecting erythrocytes from plasma. By using various methods the cells are broken and the drug is entrapped into the erythrocytes, finally they are resealed and the resultant carriers are then called "resealed erythrocytes".

Ключевые слова: Resealed Erythrocytes, storage of resealed erythrocytes, loading of of resealed erythrocytes, therapeutic application of of resealed erythrocytes, in vitro properties of of resealed erythrocytes