Drugs for Ovarian Stimulation & Pituitary Suppression -AMH -LH - Proge. Progesterone and Gonadotropin-Releasing Hormone - Update 2021

      Аннотация: Infertility Definition*Infertility is defined as the inability of a couple to bring pregnancy to term after a year of unprotected sexual intercourse. According to the WHO 8-10% of couples experience infertility, which translates to 80-100 million people. Infertility Treatment * Treatment for infertility became available owing to development in the characterization and purification of hormones. Treatment with gonadotropins and clomiphene citrate (CC) became available in 1961. The purpose of this chapter is to overview the development, structure, and mode of action of treatments for ovulation induction (OI) and controlled ovarian stimulation (COS) for assisted reproductive techniques (ARTS).Scale of the Infertility Problem * For more than 30 years, human menopausal gonadotropins (HMG) have been applied in the treatment of human infertility. Clinical implications include ovulation induction in clomiphene resistant an ovulatory women and ovarian stimulation in assisted reproduction techniques. During the last decade there has been substantial increase in the use of infertility drugs, primarily regimens incorporating urinary gonadotropins.

Ключевые слова: Drugs for Ovarian Stimulation & Pituitary Suppression -AMH -LH - Progesterone, Drug Description, Mechanism of action, Duration of Treatment, Results of Treatment, Pharmacokinetics, Drugs Available, historical overview, The Normal LH Surge, Human chorionic gonadotropin, Human Menopausal Gonadotropin, Purified Follicle-Stimulating Hormone, Quantifying & Standardizing Gonadotropin Content, Outcomes Achieved with r-hFSH Versus hMG, Individualization of Ovarian Stimulation