Expression of Cathepsin B mRNA Splice Variants in Cancer and OA. The Role of Exon 2

      Аннотация: In this book Isabel Paulin contributes whit methods, techniques, processes and procedures to obtain the distribution and levels of the Cathepsin B splice variants in different human tissue sources (osteoarthritic cartilage, colon carcinoma and normal liver). The author's work with which addresses topics like optimal efficient translation, regulated expression, polymorphism, stability of mRNA, visualization of sequencing reaction, pathological conditions, etcetera and the justifications who support the inferences that presents, as well as the extensive bibliography, will enable to approximate specialists from different fields of knowledge in the construction of an interdisciplinary object of study. Paulin sets precedent, since the late twentieth century, in the structuring of a knowledge society required and demanded by the academic community.

Ключевые слова: Cathepsin B, mRNA, Cancer, osteoarthritis, Splice Variants, Exon 2, RNase protection assay