Heterocyclic Chemistry: Pyrazoles. Synthesis, reactivity and biological activity of pyrazole derivatives

      Аннотация: This book explains the fundamental knowledge and overview of pyrazole nucleus. The aim of book is to review synthesis, reactivity and current advances of an emerging ‘new wave’ of pyrazole scaffold as potent antiproliferative agents that may target a variety of receptors such as vascular endothelial growth factor (VEGF), tyrosine kinase, Aurora-A kinase, protein kinase inhibitor, polo-like kinase inhibitors, tumor growth factor (TGF), fibroblast growth factor (FGF), BRAF kinase, and cyclin dependent kinase (CDK), which are important for management of cancer. Book will be useful for the improvement of basics of heterocyclic compounds such as pyrazole and pyrazoline.

Ключевые слова: pyrazole, vascular endothelial growth factor, BRAF kinase