Role of Immunohistochemistry in Breast Carcinoma. Molecular classification of breast carcinoma by assessing expression of ER, PR, HER2/neu, Ki-67 and CK5/6

      Аннотация: Breast cancer is the most common cancer among women both in developed and developing countries. In India, it is the 2nd leading cause of cancer among women’s preceded by cervical cancer. Breast tumors with similar histopathological appearances can exhibit divergent clinical presentations, disease aggressiveness and treatment responsiveness. Breast cancers were categorized into at least five main groups which differ markedly in terms of distinct races/ethnicities, risk factor distribution, prognosis, therapeutic treatment responsiveness, clinical outcomes and both overall survival (OS) and relapse-free survival: luminal cell-like tumors, subdivided into luminal A and B , Her-2/neu positive, basal -like (BCL), and normal breast-like group. Routine IHC evaluations of breast cancers may provide not only crucial information to guide clinical management, but also represents a valid alternative to costly genotyping assays.

Ключевые слова: breast cancer, Bloom Richardson Grading, CK 5/6, immunohistochemistry, Her-2/ne, Progesterone Receptor, Estrogen Receptor, Ki-67